Browse our Research Articles

Page 203 of 1,403
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    Lutian Yao, Jiawei Lu ... Maurizio Pacifici
    Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.
    1. Computational and Systems Biology

    Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

    Silvia Liu, Yan-Ping Yu ... Jian-Hua Luo
    A synthetic long-read single-cell sequencing reveals critical mutation isoform expression patterns in human liver cancer cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

    Caroline M Boyd, Sundharraman Subramanian ... Kimberley D Seed
    A phage parasite encodes an external scaffolding protein to pirate and rearrange phage-encoded coat proteins to more efficiently transfer the phage parasite genome to new hosts and limit phage production.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3

    Tomoki Kita, Kyoko Chiba ... Shinsuke Niwa
    Comparative biochemical analysis of a nematode-specific kinesin-3 shed light on the mechanism of kinesin-3 dimerization and activation.
    1. Neuroscience

    Multiple NTS neuron populations cumulatively suppress food intake

    Weiwei Qiu, Chelsea R Hutch ... Darleen Sandoval
    Analyses reveal that multiple NTS neuron types act cumulatively in the suppression of feeding, that the abrogation of food intake by multiple non-aversive populations fails to promote aversive responses, and that there exist additional NTS populations that modulate food intake.
    1. Cancer Biology

    Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

    Gehad Youssef, Luke Gammon ... Adrian Biddle
    Cancer stem cells that have undergone EMT are identified in the region surrounding metastatic human oral tumours in a retrospective cohort study, and these are predictive of metastatic outcome in an image-based machine learning approach.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals

    Irina AD Mancini, Riccardo Levato ... Jos Malda
    Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
    1. Neuroscience

    The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons

    Tenzin Ngodup, Tomohiko Irie ... Laurence O Trussell
    Noradrenergic receptors can control the spontaneous electrical firing of neurons by inhibiting a Na+ channel known as NALCN using a pathway shared by metabotropic GABA receptors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
    Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.