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Constitutive deficiency of AP2γ transcription factor impairs hippocampal glutamatergic neurogenesis and induces alterations on limbic-cortical connectivity that contribute to anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.

Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.

Heat shock factor 1 is involved in estrogen-induced chromatin remodeling in estrogen receptor-positive breast cancer cells.

Drosophila larvae show taste multimodality and combinatorial sensing at gustatory organ level but also systemically as they employ complementary external and internal taste in sugar detection.

Recognition of SARS-CoV-2 spike protein by innate immune sensor TLR2 leads to the induction of inflammatory mediators and constitutes a mechanism for cytokine storm during COVID-19.

The invasive tick Hyalomma marginatum relies on a dual partner nutritional system to provide B vitamins and avoid nutritional deficiencies due to its exclusive blood diet.

Deficiency of capicua, a transcription factor that suppresses autoimmunity, impairs positive and negative selection processes by attenuating TCR signaling in CD4⁺CD8⁺ double-positive thymocytes.

Functional analysis reveals a distinct mode of action of the allosteric modulators in the GABA_B receptor in a pocket that is formed only in the active state and identifies a region in the GABA_B2 subunit important for allosteric agonism.

The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.

The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.