Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
The formation of HIV-1 particles requires a bending of the membrane that cannot be achieved by the Gag protein alone and thus there is need for the I-BAR protein IRSp53 to aid in the formation of HIV-1 buds.
Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.
Martina Dal Bello, Alfonso Pérez-Escudero ... Jeff Gore
Worms' attraction to pheromones turns into repulsion when a food patch is depleted, helping them avoid already exploited territories and search for new food sources.
Mariena JA van der Plas, Jun Cai ... Artur Schmidtchen
Peptidomics method development and analysis of qualitative differences of peptide patterns in human wound fluids provide potential biomarkers for wound healing and infection.
Akinobu Watanabe, Amy M Balanoff ... Mark A Norell
More integrated brains in crown birds evolved through a mosaic assembly of new evolutionary and developmental dynamics across neuroanatomical regions that occurred along the dinosaur-bird transition.
Viktor J Radermacher, Vincent Fernandez ... Jonah N Choiniere
A new specimen of Heterodontosaurus elucidates how ornithischian dinosaurs evolved a body plan substantially different from that of other dinosaurs and what these differences meant for their breathing.
