Browse our Research Articles

Page 651 of 1,403
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene, Eli-Eelika Esvald ... Tõnis Timmusk
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

    Zharko Daniloski, Tristan X Jordan ... Neville E Sanjana
    A pervasive mutation in the Spike protein of the coronavirus that causes COVID-19 results in virions that are up to eightfold more infectious.
    1. Cancer Biology
    2. Immunology and Inflammation

    Human primed ILCPs support endothelial activation through NF-κB signaling

    Giulia Vanoni, Giuseppe Ercolano ... Sara Trabanelli
    Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
    1. Cell Biology
    2. Developmental Biology

    Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila

    Shichao Yu, Fangzhou Luo, Li Hua Jin
    Rab5 and Rab11 regulate hematopoietic homeostasis in Drosophila, and this process involves the JNK, Toll, and Ras/EGFR signaling pathways and autophagy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova, Daniel E Sturdevant ... Alexander G Pletnev
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Immunology and Inflammation
    2. Medicine

    Perinatal granulopoiesis and risk of pediatric asthma

    Benjamin A Turturice, Juliana Theorell ... Patricia W Finn
    Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pentameric protein ring with novel architecture is required for herpesviral packaging

    Allison L Didychuk, Stephanie N Gates ... Britt A Glaunsinger
    The first structures of Kaposi’s sarcoma-associated herpesvirus ORF68 and Epstein–Barr virus BFLF1, conserved and essential proteins required in herpesviruses, reveal new insights into viral genome packaging.
    1. Neuroscience

    Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

    Daniel Powell, Sara A Haddad ... Eve Marder
    The mechanism that couples two rhythmic circuits is maintained over a large temperature range although both circuits are temperature-sensitive.
    1. Immunology and Inflammation

    The kinase PDK1 is critical for promoting T follicular helper cell differentiation

    Zhen Sun, Yingpeng Yao ... Shuyang Yu
    PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Residue-by-residue analysis of cotranslational membrane protein integration in vivo

    Felix Nicolaus, Ane Metola ... Gunnar von Heijne
    The cotranslational membrane integration of three multispanning Escherichia coli inner membrane proteins is followed using force profile analysis, uncovering unexpected complexities in the membrane integration process.