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A novel experimental approach reveals how mechanical force acting on the skin is converted into electrical signaling in sensory neurons to evoke the sensation of touch.

Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.

Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.

Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.

Crystal structural analysis reveals a novel reversible pan-inhibitor of TEA domains with enhanced potency adopts a unique binding mode.

Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.

The Cryo-EM structural and biochemical analysis provides a framework for understanding the working mechanism of ALDP.

Stimulus representation in primary visual cortex rebounds to its original state following therapeutic sensory deprivation in adults.

Drosophila flies infer value to olfactory stimuli based on the previously repeatedly presented associative structure between two odorants.

Mammalian cells were engineered to synthesize valine, a metabolic capacity that had been lost from the lineage of higher eukaryotes for >500 million years.