Browse our Short Reports

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    1. Plant Biology

    Arabidopsis transcriptome responses to low water potential using high-throughput plate assays

    Stephen Gonzalez, Joseph Swift ... Joseph R Ecker
    The 'low water' agar assay provides a reliable and practical high-throughput method for studying plant molecular signaling responses to drought stress.
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    Short Report
    • Valuable
    • Solid
    1. Genetics and Genomics

    Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

    Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
    Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
    1. Neuroscience

    Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

    Blake J Laham, Isha R Gore ... Elizabeth Gould
    Adult-born granule cell projections are necessary for CA2 network activity and retrieval of developmental social memories.
    1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden
    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Epidemiology and Global Health

    A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

    Zhanwei Du, Lin Wang ... Lauren A Meyers
    Broader global access to Paxlovid, coupled with appropriately timed treatment, can mitigate the severity and transmission of SARS-Cov-2 as the virus and the landscape of immunity continue to evolve.
    1. Cell Biology
    2. Neuroscience

    Synapsin E-domain is essential for α-synuclein function

    Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler
    Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Neuroscience

    Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

    Geoffroy Delamare, Yosif Zaki ... Claudia Clopath
    Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

    Ibtisam Ibtisam, Alexei F Kisselev
    Genetic and biochemical approaches reveal that mammalian cells possess a novel DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after clinically relevant pulse treatment with proteasome inhibitors.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

    Masaya Harada, Laia Serratosa Capdevila ... Tommaso Patriarchi
    Optogenetic manipulation and photometry recordings in the lateral hypothalamus show how interactions between dopamine and orexin systems underlie reward expectation revealing dopaminergic modulation of orexinergic activity via D2 receptors.
    1. Neuroscience

    The pelvic organs receive no parasympathetic innervation

    Margaux Sivori, Bowen Dempsey ... Jean-François Brunet
    Of the two divisions proposed long ago to describe the autonomic nervous system, thoraco-lumbar sympathetic and cranio-sacral parasympathetic, the latter finds no support from transcriptionally defined neuron types.
    Version of Record
    Short Report
    • Useful
    • Incomplete