Zhenzhen Ma, Alexander L Starr ... Hunter B Fraser
Cis-acting changes account for most methylation divergence between humans and chimpanzees, with lineage-specific selection on gene expression and promoter methylation at pathways tied to human speech, cognition, and disease susceptibility.
Synthetic torpor induced in a species that does not naturally hibernate protects the heart from ischaemia-reperfusion injury, pointing to a novel translatable strategy for improving outcomes after myocardial infarction.
Loss of Shank3 destabilizes neuronal activity in the taste cortex and impairs aversive taste learning in mice, revealing how autism-associated genes compromise flexible sensory encoding in sensory cortices to influence behavior.
