Browse the latest research

Page 7 of 1,844
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

    Adithi Sundaresh, Dimitri Meistermann ... Helena Kilpinen
    Molecular and morphological profiles of developing neurons in vitro uncover the cellular dynamics of human neurodevelopment and related disease.
    1. Cell Biology

    Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.
    1. Neuroscience

    Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice

    Sarah G Donofrio, Cheryl Brandenburg ... Roy V Sillitoe
    Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional organization of the cerebellum.
    1. Neuroscience

    Individual differences in tail risk sensitive exploration using Bayes-adaptive Markov decision processes

    Tingke Shen, Peter Dayan
    A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
    1. Epidemiology and Global Health

    Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

    Pablo Ruiz Cuenca, Fábio N Souza ... Emanuele Giorgi
    Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.
    1. Neuroscience

    Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction

    Ramesh Chittajallu, Anna Vlachos ... Chris J McBain
    A pharmacogenetic approach provides a foundational dataset describing the influence of opioids on synaptic processing in a brain microcircuit known to be critical for driving hedonic behaviors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Executive Resources Shape the Impact of Language Predictability Across the Adult Lifespan

    Merle Schuckart, Sandra Martin ... Jonas Obleser
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

    Francine Carla Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid