Browse the latest research

Page 7 of 1,813
    1. Cancer Biology

    SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

    Ricardo J Mack, Natasha M Flores ... Or Gozani
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

    Rita Sianga-Mete, Penelope Hartnady ... Darren Patrick Martin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
    1. Chromosomes and Gene Expression

    Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

    Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

    Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Thrifty wide-context models of B cell receptor somatic hypermutation

    Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
    Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
    1. Neuroscience

    Mesolimbic dopamine ramps reflect environmental timescales

    Joseph R Floeder, Huijeong Jeong ... Vijay Mohan K Namboodiri
    Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

    Tony KY Lim, Anne Ritoux ... Ewan St John Smith
    Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
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