Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

   Sandeep K. Ravala, Sendi Rafael Adame-Garcia ... John J. G. Tesmer
2. 1. Biochemistry and Chemical Biology

   Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

   George N. Bendzunas, Dominic P Byrne ... Natarajan Kannan
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   MEMO1 binds iron and modulates iron homeostasis in cancer cells

   Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   X-ray structure and enzymatic study of a bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

   Isabelle Petit-Hartlein, Annelise Vermot ... Franck Fieschi

   Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.
5. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Guanidine production by plant homoarginine-6-hydroxylases

   Dietmar Funck, Malte Sinn ... Jörg S Hartig

   2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.
6. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   The rules of sex and strain: deciphering the chemical language of inbred and wild mouse conspecific scents

   Maximilian Nagel, Marco Niestroj ... Marc Spehr
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

   Andrew P. Latham, Longchen Zhu ... Bin Zhang
8. 1. Biochemistry and Chemical Biology
   2. Medicine

   Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

   Giulia Leanza, Francesca Cannata ... Nicola Napoli

   In individuals with type 2 diabetes, downregulation of bone canonical Wnt signaling is linked to higher levels of advanced glycation end-products within the bone, contributing to lower bone strength.
9. 1. Biochemistry and Chemical Biology

   The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

   Valentin Bohl, Nele Merret Hollmann ... Axel Mogk

   The bacterial AAA+ chaperone ClpL recognizes aggregated proteins via multiple contacts of its unique N-terminal domain and refolds them with high efficiency providing superior heat resistance.
10. 1. Biochemistry and Chemical Biology

    A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

    Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori