Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Dependence of Nucleosome Mechanical Stability on DNA Mismatches

   Thuy T. M. Ngo, Bailey Liu ... Taekjip Ha
2. 1. Structural Biology and Molecular Biophysics

   Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies

   Christian Galicia, Giambattista Guaitoli ... Wim Versées
3. 1. Structural Biology and Molecular Biophysics
   2. Developmental Biology

   Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

   Arne Elofsson, Ling Han ... Luca Jovine
4. 1. Structural Biology and Molecular Biophysics

   The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

   Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
5. 1. Structural Biology and Molecular Biophysics

   LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

   Colin H Peters, Rohit K Singh ... John R Bankston
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

   Andrew P. Latham, Longchen Zhu ... Bin Zhang
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Effect of α-tubulin acetylation on the doublet microtubule structure

   Shun Kai Yang, Shintaroh Kubo ... Khanh Huy Bui

   Cryo-EM studies of doublet microtubules from wild-type and acetylation mutants suggest that acetylation of K40 affects the lateral rotational angle between protofilaments, leading to changes in the structure and stability.
8. 1. Structural Biology and Molecular Biophysics

   Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli

   Sebastian Jojoa-Cruz, Adrienne E Dubin ... Andrew B Ward

   Structural comparison and electrophysiology of OSCA channels shed light on potential structural features influencing response to poke stimulus.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

   Tien M Phan, Young C Kim ... Jeetain Mittal

   Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
10. 1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    The molecular basis of Abelson kinase regulation by its αI-helix

    Johannes Paladini, Annalena Maier ... Stephan Grzesiek

    High-resolution NMR data and precise kinase activity assays on Abelson kinase bearing mutations in its αI-helix identify the αI-helix parts involved in disassembly of Abelson’s regulatory core and kinase activation.