Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

    Jing Xie, Yafei Xu ... Qiancheng Song
    Osteocytes, sensing mechanical stimulation generated by exercise, inhibit the proliferation of non-small cell lung cancer cells and sustain their dormancy by releasing small extracellular vesicles containing tumor-suppressive micro-RNAs.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Cancer Biology

    DePARylation is critical for S phase progression and cell survival

    Litong Nie, Chao Wang ... Junjie Chen
    1. Cell Biology
    2. Cancer Biology

    Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics

    Timothy J. Walker, Eduardo Reyes-Alvarez ... Lois M. Mulligan
    1. Cancer Biology

    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

    Fei Yue, Amy T. Ku ... Yi Li
    1. Cancer Biology

    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

    Carolyn M Jablonowski, Waise Quarni ... Jun Yang
    Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Päivi Ojala
    University of Helsinki, Finland
  4. See more editors