Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology

   A logic-incorporated gene regulatory network deciphers principles in cell fate decisions

   Gang Xue, Xiaoyi Zhang ... Zhiyuan Li

   A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.
2. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

   Ritwik Maity, Xuepei Zhang ... Javier Sancho
3. 1. Cell Biology
   2. Computational and Systems Biology

   De novo-designed minibinders expand the synthetic biology sensing repertoire

   Zara Y. Weinberg, Sarah S. Soliman ... Hana El-Samad
4. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Experimental evolution for the recovery of growth loss due to genome reduction

   Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

   Weichen Song, Yongyong Shi, Guan Ning Lin

   Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
6. 1. Computational and Systems Biology

   Genome-scale annotation of protein binding sites via language model and geometric deep learning

   Qianmu Yuan, Chong Tian, Yuedong Yang

   Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.
7. 1. Neuroscience
   2. Computational and Systems Biology

   Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach

   Mu Qiao
8. 1. Computational and Systems Biology
   2. Physics of Living Systems

   The French flag problem revisited: Creating robust and tunable axial patterns without global signaling

   Stephan Kremser, Gabriel Vercelli, Ulrich Gerland
9. 1. Cell Biology
   2. Computational and Systems Biology

   Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

   Thomas Grandits, Christoph M Augustin ... Alexander Jung

   Neural networks can emulate normal and abnormal human ventricular action potentials accurately and potentially much faster than regular simulations paving the way for more efficient quantitative systems pharmacology studies.
10. 1. Computational and Systems Biology

    Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

    Antony M Jose