Chromosomes and Gene Expression

Latest articles

1. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

   Lucie Crhak Khaitova, Pavlina Mikulkova ... Karel Riha

   The sensitivity of Arabidopsis meiotic centromeres to heat stress suggests that centromere function is one of the key determinants of plant reproduction under rising temperatures.
2. 1. Developmental Biology
   2. Chromosomes and Gene Expression

   N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

   Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
3. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

   Richard C. Centore, Luis M. M. Soares ... Steven F. Bellon
4. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

   Gregory C. Howard, Jing Wang ... William P. Tansey
5. 1. Chromosomes and Gene Expression

   Post-transcriptional splicing can occur in a slow-moving zone around the gene

   Allison Coté, Aoife O'Farrell ... Arjun Raj

   The existence of a slow-moving zone around the transcription site may unify conflicting models of co-transcriptional versus post-transcriptional mRNA splicing.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

   Maria L Adelus, Jiacheng Ding ... Casey E Romanoski

   Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
7. 1. Chromosomes and Gene Expression

   Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

   Fujun Zhou, Julie M Bocetti ... Jon R Lorsch

   A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.
8. 1. Chromosomes and Gene Expression

   Artificially inserted G-quadruplex DNA secondary structures induce long-distance chromatin activation

   Shuvra Shekhar Roy, Sulochana Bagri ... Shantanu Chowdhury
9. 1. Chromosomes and Gene Expression

   Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

   Mengxue Tian, Zhenjia Wang ... Chongzhi Zang

   The ~20,000 origins of replication in human cell lines that are reproducibly identified by multiple techniques in multiple cell lines are distant from known origin recognition complex and MCM2-7-binding sites.
10. 1. Chromosomes and Gene Expression

    A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

    Kamil Pabis, Diogo Barardo ... Brian K Kennedy

    A majority of transcribed transposons during aging are derived from transcriptional defects, most notably intron retention and transcriptional readthrough.