Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Saccharomyces cerevisiae Rev7 regulates DSB repair pathway choice through binding and blocking Mre11 nuclease and Rad50 ATPase activities

   Sugith Badugu, Kshitiza M. Dhyani ... Kalappa Muniyappa
2. 1. Genetics and Genomics

   De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects

   Mengqi Ma, Yiming Zheng ... Hugo J. Bellen
3. 1. Genetics and Genomics

   Mono-methylated histones control PARP-1 in chromatin and transcription

   Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
4. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

   Weichen Song, Yongyong Shi, Guan ning Lin

   Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
5. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Transposable elements regulate thymus development and function

   Jean-David Larouche, Céline M Laumont ... Claude Perreault

   Multiomic analyses provide new insights into the involvement of transposable elements in T-cell development in the thymus and central tolerance induction.
6. 1. Developmental Biology
   2. Genetics and Genomics

   ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

   Debashish U. Menon, Prabuddha Chakraborty ... Terry Magnuson
7. 1. Genetics and Genomics

   Explaining the counter-intuitive effectiveness of trophectoderm biopsy for PGT-A using computational modelling

   Benjamin M Skinner, Manuel Viotti ... Peter JI Ellis
8. 1. Genetics and Genomics

   Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

   Wenjing Liu, Shujin Li ... Xianjun Zhu
9. 1. Genetics and Genomics
   2. Cancer Biology

   DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

   Jose Mario Bello Pineda, Robert K. Bradley
10. 1. Genetics and Genomics

    Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

    Pianpian Zhao, Zhifeng Sheng ... Hou-Feng Zheng

    Genetically determined type 2 diabetes (T2D) may not increase the risk of fracture, but managing T2D-related risk factors is crucial to prevent fracture in patients with T2D.