Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Neuroscience

    Exposure Therapy: Enhancing fear extinction

    Sydney Trask, Nicole C Ferrara
    Gradually reducing a source of fear during extinction treatments may weaken negative memories in the long term.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Ecology

    Mutualistic Relationships: Balancing metabolism and reproduction

    Songdou Zhang, Shiheng An
    The bacterium responsible for a disease that infects citrus plants across Asia facilitates its own proliferation by increasing the fecundity of its host insect.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Lactation: How to pause fertility

    Aleisha M Moore
    Prolactin suppresses the ovarian cycles of lactating mice by directly repressing the activity of a cell population known as kisspeptin neurons.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Immunology and Inflammation

    Bacterial Growth: The SagA of E. faecium

    Rishika Prasad, Robert R Jenq
    An enzyme that remodels the cell wall of Enterococcus faecium helps these gut bacteria to divide and generate peptide fragments that enhance the immune response against cancer.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Immune Response: Investigating the role of vitamin D in asthma

    Siddhant Sharma, Mayank Garg
    Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression

    Epigenetics: Linking environmental factors and gene regulation

    Signe Penner-Goeke, Elisabeth B Binder
    A technique called mSTARR-seq sheds light on how DNA methylation may shape responses to external stimuli by altering the activity of sequences that control gene expression.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Chromatin Remodeling: The voyage is as important as the harbor

    Anton Sabantsev, Sebastian Deindl
    To find nucleosomes, chromatin remodelers slide and hop along DNA, and their direction of approach affects the direction that nucleosomes slide in.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Proteostress: Mechanosensory neurons under pressure

    Erin Cram
    A build-up of eggs in the uterus of the nematode C. elegans triggers the release of large extracellular vesicles, called exophers, from neurons that are sensitive to mechanical forces.
    Insight
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Perception: How larvae feel the world around them

    Jimena Berni
    A complete map of the external sense organs shows how fruit fly larvae detect different aspects of their environment.
    Insight
    Formats available:
    • HTML
    • PDF