Neuroscience

Neuroscience

eLife reviews research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Neuroscience

    BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons

    Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel ... Nicolás Unsain
    An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.
    1. Neuroscience

    Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

    Elise J Meijer, Marissa Mueller ... Zoltan Molnar
    Layer 6b neurons shape state-dependent brain rhythms and responses to orexin, revealing an underappreciated cortical mechanism that may help explain disrupted sleep-wake regulation in neurodevelopmental and psychiatric disorders more broadly.
    1. Neuroscience

    Hilar mossy cells control structural and functional organization in the dentate gyrus

    Corwin R Butler, Connor R Squellati ... Eric Schnell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Correctness is its own reward: bootstrapping error signals in self-guided reinforcement learning

    Ziyi Gong, Fabiola Duarte ... John Pearson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    A theory of multi-task computation and task selection

    Owen Marschall, David G Clark, Ashok Litwin-Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep

    Justin D Shin, Michael Satchell ... Shantanu P Jadhav
    Rapid eye movement (REM) sleep organizes sparse, sequential cortical reactivation through chains of prefrontal high-frequency oscillations coupled to hippocampal theta, an inter-regional dialogue distinct from that of non-REM ripples.
    1. Neuroscience

    Preserved cerebellar functions despite structural degeneration in older adults

    Anda de Witte, Anouck Matthijs ... Jean-Jacques Orban de Xivry
    Cerebellar-dependent functions are mostly maintained or even enhanced across the lifespan, with cerebellar-mediated motor abilities remaining intact despite degeneration, in contrast to non-cerebellar measures.
    1. Neuroscience

    Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function

    Grit Bornschein, Max Schwarze ... Hartmut Schmidt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Synaptic connectome of a neurosecretory network in the Drosophila brain

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Differential locus coeruleus–hippocampus interactions during offline states

    Mingyu Yang, Oxana Eschenko
    Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implications for synaptic and systems consolidation.

Senior editors

  1. John Huguenard
    Stanford University School of Medicine, United States
  2. Huan Luo
    Peking University, China
  3. Kate Wassum
    University of California, Los Angeles, United States
  4. See more editors