Neuroscience

Neuroscience

eLife reviews research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

    Harry Clark, Matthew F Nolan
    Anchoring of grid firing fields to task environments is consistent with roles specifically in path integration rather than spatial localisation in general.
    1. Neuroscience

    Neurophysiological trajectories in Alzheimer’s disease progression

    Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
    Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

    Zhenyong Wu, Grant F Kusick ... Shigeki Watanabe
    The calcium-binding proteins synaptotagmin 7 and Doc2α act sequentially during asynchronous neurotransmitter release.
    1. Developmental Biology
    2. Neuroscience

    Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells

    Tariq Zaman, Daniel Vogt ... Michael R Williams
    The transmembrane protein Kit Ligand and the Kit receptor tyrosine kinase are required for synapse function between specific cell types in the mouse cerebellum.
    1. Neuroscience

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    Hideo Hagihara, Hirotaka Shoji ... Tsuyoshi Miyakawa
    Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.
    1. Neuroscience

    Dopamine lesions alter the striatal encoding of single-limb gait

    Long Yang, Deepak Singla ... Sotiris C Masmanidis
    Striatal neurons preferentially fire at specific phases of the gait cycle, and the strength of gait encoding is selectively increased in indirect pathway neurons following dopamine lesions.
    1. Neuroscience

    Tracking subjects’ strategies in behavioural choice experiments at trial resolution

    Silvia Maggi, Rebecca M Hock ... Mark D Humphries
    A new Bayesian algorithm for tracking subjects’ choice strategies on every trial reveals when subjects learn and what they tried while doing so, providing strong evidence that reward- and loss-driven exploration change independently.

Senior editors

  1. Sofia J Araújo
    University of Barcelona, Spain
  2. Laura Colgin
    The University of Texas at Austin Center for Learning and Memory, United States
  3. Kate Wassum
    University of California, Los Angeles, United States
  4. See more editors