Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Plastic vasomotion entrainment

    Daichi Sasaki, Ken Imai ... Ko Matsui
    Entrainment of global synchronization of vasomotion induced by repeated presentation of oscillating visual stimuli may facilitate efficient energy delivery to meet the demand for coordinated neuronal activity and circuit reorganization.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

    Lucie Crhak Khaitova, Pavlina Mikulkova ... Karel Riha
    The sensitivity of Arabidopsis meiotic centromeres to heat stress suggests that centromere function is one of the key determinants of plant reproduction under rising temperatures.
    1. Cell Biology

    High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

    Wan-ping Yang, Mei-qi Li ... Qian-qian Luo
    Hypobaric hypoxia exposure initiates splenic ferroptosis, reducing red pulp macrophages and exacerbating high-altitude polycythemia by impairing erythrophagocytosis and increasing red blood cell retention.
    1. Medicine
    2. Neuroscience

    Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

    Flora Moujaes, Jie Lisa Ji ... Alan Anticevic
    There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.
    1. Ecology

    The push–pull intercrop Desmodium does not repel, but intercepts and kills pests

    Anna L Erdei, Aneth B David ... Teun Dekker
    Instead of repelling, Desmodium, a hallmark of pest suppressive sustainable intercropping, acts as a mechanical and developmental barrier to larvae, thereby truncating population development.
    1. Microbiology and Infectious Disease

    High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

    Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
    E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.
    1. Neuroscience

    Disruption of awake sharp-wave ripples does not affect memorization of locations in repeated-acquisition spatial memory tasks

    Lies Deceuninck, Fabian Kloosterman
    Hippocampal sharp-wave ripples are not required for rats to successfully perform spatial tasks that rely on memorization of locations at short timescales.
    1. Medicine

    Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

    Jinjing Chen, Ruoyu Wang ... Jongsook Kemper
    Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
    1. Cell Biology

    Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

    Fabian Link, Alyssa Borges ... Markus Engstler
    The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
    1. Microbiology and Infectious Disease

    A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

    Swati Jain, Gherman Uritskiy ... Venigalla B Rao
    HIV escapes human immune pressure through a single mutation in V2 domain of envelope protein leading to emergence of mutant-specific broadly reactive antibodies, a phenomenon recapitulated in combinatorial vaccine design.