Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.
Hippocampal sharp-wave ripples are not required for rats to successfully perform spatial tasks that rely on memorization of locations at short timescales.
Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
Brain region-specific profiling of O-GlcNAcylation interactome in Drosophila mushroom body suggests that hypo-O-GlcNAcylation impacts cognitive function by regulating translational activity.
HIV escapes human immune pressure through a single mutation in V2 domain of envelope protein leading to emergence of mutant-specific broadly reactive antibodies, a phenomenon recapitulated in combinatorial vaccine design.
2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.
Biochemical and instrumental analysis showed that the membrane-induced exposure of myristoyl from the MA protein of Mason-Pfizer monkey virus triggers allosteric conformational changes resulting in MA oligomerization and unfolding of the cleavage site between MA and downstream domains of Gag.
A single-nucleus transcriptomic atlas reveals the molecular signatures and trajectory dynamics of the neurogenic lineage in the human hippocampus during neonatal development, adulthood, aging, and after injury.
Robert Horvath, Nikolaos Minadakis ... Anne C Roulin
Disentangling the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon.
