Figure 4. | The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

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The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

Figure 4.

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University of California, San Francisco, United States
Figure 4.
Download figureOpen in new tabFigure 4. Cooperative assembly of a nuclear export complex with human Crm1 enhances nuclear export and virion production.

Human Crm1 (top) associates with Rev-RRE with higher affinity than murine Crm1 (bottom) due to species-specific residues that form the dimer interface (gold). This increased association amplifies into even larger differences in nuclear export activity and virion assembly between the two Crm1s.

DOI: http://dx.doi.org/10.7554/eLife.04121.012