• Figure 4.
    Download figureOpen in new tabFigure 4. Cooperative assembly of a nuclear export complex with human Crm1 enhances nuclear export and virion production.

    Human Crm1 (top) associates with Rev-RRE with higher affinity than murine Crm1 (bottom) due to species-specific residues that form the dimer interface (gold). This increased association amplifies into even larger differences in nuclear export activity and virion assembly between the two Crm1s.

    DOI: http://dx.doi.org/10.7554/eLife.04121.012