Figure 4—figure supplement 5. | Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

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Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

Figure 4—figure supplement 5.

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University of California, San Francisco, United States; University of Pennsylvania, United States
Figure 4—figure supplement 5.
Download figureOpen in new tabFigure 4—figure supplement 5. Inference results from three validation experiments.

(A) Three parameter sets, spanning a range of values of g¯, were selected from the prior distribution. The parameter sets produced substantial differences in mean levels of positive sense (solid) and negative sense (dashed) RNA over time. (B) Distribution of g¯in the prior, round one posterior, and round two posterior for the ‘low’ parameter set (g¯ = 3.20). (C) Distribution of g¯in the prior, round one posterior, and round two posterior for the ‘middle’ parameter set (g¯ = 5.97). (D) Distribution of g¯in the prior and round one posterior (round two was not performed due to the high degree of convergence in round one) for the ‘high’ parameter set (g¯ = 8.58).

DOI: http://dx.doi.org/10.7554/eLife.03753.013