• Figure 1.
    Download figureOpen in new tabFigure 1. Illustrations of the genealogies of different replication modes.

    Red dots indicate positive-sense strands. Blue dots indicate negative-sense templates. Stamping machine (SM) progeny are one generation from the initial infecting genome (left). In an example of geometric replication (GR), progeny are an average of 2.33 generations from the initial infecting genome (right).

    DOI: http://dx.doi.org/10.7554/eLife.03753.003

    Figure 2.
    Download figureOpen in new tabFigure 2. The replication cycle of poliovirus as represented in our model.

    Numbered steps correspond to sections and equations in the ‘Materials and methods’.

    DOI: http://dx.doi.org/10.7554/eLife.03753.004

    Figure 5.
    Download figureOpen in new tabFigure 5.

    Left: mean mutation frequencies for three parameter sets (‘low’, g¯ = 3.94; ‘best’, g¯ = 4.65; ‘high’, g¯ = 5.76). Mutation rate is 2 × 10−5 per replication event; ‘relative replication rate’ reflects the reduced probability of a mutant template to replicate, relative to an unmutated strand. Grey lines indicate the expected mean for each parameter set with no selection (deficit of zero); the black line shows the mutation rate in one replication step, and therefore the expected frequency when mutants cannot replicate. Bars indicate 95% confidence intervals. Right: distributions of g of progeny from single cell infections for three parameter sets (‘low’, g¯ = 3.94; ‘best’, g¯ = 4.65; ‘high’, g¯ = 5.76).

    DOI: http://dx.doi.org/10.7554/eLife.03753.016