Figure 8. | Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

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Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

Figure 8.

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California Institute of Technology, United States
Figure 8.
Download figureOpen in new tabFigure 8. dbh is required for Hcrt neuron-induced increased locomotor activity.

(A, C) Representative locomotor activity traces for dbh−/ and sibling control larvae without (A) and with (C) the hcrt:ChR2-EYFP transgene during blue light exposure. (B, D) Average locomotor activity relative to sibling controls. Data is pooled from 2 (B) or 3 (D) experiments. Data is represented as mean ± s.e.m. and is plotted as percentage of dbh+/+ (B) or hcrt:ChR2-EYFP; dbh+/+ (D). n indicates number of larvae. *, p < 0.05 and ***, p < 0.0001 by one-way ANOVA followed by Tukey's test to correct for multiple comparisons.

DOI: http://dx.doi.org/10.7554/eLife.07000.023