Figure 3—figure supplement 1. | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

Figure 3—figure supplement 1.

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Champalimaud Foundation, Portugal
Figure 3—figure supplement 1.
Download figureOpen in new tabFigure 3—figure supplement 1. Basic stride parameters for pcd are are not different from their size-matched controls.

(A) Histogram of walking speeds, divided in 0.05 m/s speed bins for pcd (purple, N = 3 mice, n = 3052 strides), littermate controls (green, N = 7 mice, n = 2256 strides) and size matched controls (black, N = 11 mice, n = 3400 strides). (B) Histogram of stride counts by weight for size-matched controls and pcd. (CE) Basic stride parameters. For each parameter, thick lines represent the prediction, from the mixed-effects models derived from wildtype data in Figure 2 (including speed and weight as predictor variables), for each group. Pcd (average weight = 12g; purple line), control littermates (average weight = 26g; blue line) and size-match controls (average weight = 12g; black line). (C) Stride length values vs walking speed for pcd, littermate controls and size-matched controls (median ±25th, 75th percentile). Data are represented by thin lines and shadows, thick lines are model predictions. (D, E) Temporal measures of the step cycle; cadence (inverse of stride duration) and stance duration, respectively (median ±25th, 75th percentile).

DOI: http://dx.doi.org/10.7554/eLife.07892.011