Figure 3—figure supplement 2. | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

Figure 3—figure supplement 2.

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Champalimaud Foundation, Portugal
Figure 3—figure supplement 2.
Download figureOpen in new tabFigure 3—figure supplement 2. 3D paw trajectories for wildtype controls and pcd.

(AC) Average 3D trajectories for front right paw of wildtype control group (N = 34; n = 9602 strides) during swing phase. Traces are binned and color coded by walking speed. (A) Instantaneous forward (x) velocity. (B) side-to-side (y) excursion (C) vertical (z) position relative to ground. (DF) Same as above but for hind right paw of wildtype control group. (GI) Paw trajectories for pcd and size-matched controls. (G) Hind right paw x-trajectories. (H) Hind right paw vertical (z) position relative to ground during swing. In pcd, hind paws were lifted higher than forepaws, and their peak positions varied more steeply with speed, (F[153.02,1] = 5.64,p < 0.05).

DOI: http://dx.doi.org/10.7554/eLife.07892.012