Figure 5—figure supplement 2. | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

Figure 5—figure supplement 2.

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Champalimaud Foundation, Portugal
Figure 5—figure supplement 2.
Download figureOpen in new tabFigure 5—figure supplement 2. Results summary for young pcd and size-matched controls.

(A) Average vertical (z) position of FR paw relative to ground during swing for young (<P55) pcd (purple) and size-matched controls (compare with Figure 3G). Line thickness represents increasing speed. (BD) Polar plots indicating the phase of the step cycle in which each limb enters stance, aligned to stance onset of FR paw (red). Distance from the origin represents walking speed. Left, size-matched control mice. Right, young pcd (compare with Figure 4A). (C) Averaged lateral trajectory of tail segment 8 relative to the mid-point between the hind paws, for animals walking at 0.1–0.2 m/s, for size-matched controls (black), and young pcd (purple) (compare with Figure 5A). (D) Phase of maximum correlation between the forward position of the hind paws and the lateral trajectories of each tail segment (green-yellow gradient) for size-matched controls (left) and pcd (right) (compare with Figure 5D,E).

DOI: http://dx.doi.org/10.7554/eLife.07892.017