Figure 6. | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

Figure 6.

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Champalimaud Foundation, Portugal
Figure 6.
Download figureOpen in new tabFigure 6. Visualization of impaired whole-body coordination in pcd.

(A) Ribbon plots showing average vertical (z) trajectories for nose, paw and select tail (2, 5, 8, 11, 14) segments for size-matched control (Left, N = 11)) and pcd (Right, N = 3) mice walking at 0.20–0.25 m/s. Data are presented relative to 100% of the stride cycle of the FR paw (x-axis). Nose and paw trajectories are z position relative to floor; tail is z relative to floor with mean vertical position of the of base of the tail subtracted for clarity. (B) Matrix of correlation coefficients computed for average vertical trajectories of control (Left) and pcd (Right). Color bar is value of correlation coefficient.

DOI: http://dx.doi.org/10.7554/eLife.07892.019