Table 1. | Cell-to-cell infection by HIV contributes over half of virus infection

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Cell-to-cell infection by HIV contributes over half of virus infection

Table 1.

Affiliation details

Kyushu University, Japan; Japan Science and Technology Agency, Japan; Kyoto University, Japan; University of Tokyo, Japan; Hospital Saint Louis, France; Université Paris Diderot, Sorbonne Paris Cité, France; Tokyo University of Agriculture, Japan
Table 1.

Parameters estimated by mathematical-experimental analysis

DOI: http://dx.doi.org/10.7554/eLife.08150.004

Parameter nameSymbolUnitExp. 1Exp. 2Exp. 3Ave. ± S.D.
Parameters obtained from simultaneous fit to time-course experimental dataset
 Rate constant for cell-free infectionβ10−6 × (p24 day)−15.59* (3.54–8.41)3.27 (2.05–5.01)3.70 (2.28–5.77)4.18 ± 1.41
 Rate constant for cell-to-cell infectionω10−6 × (cell day)−10.88 (0.45–1.39)1.25 (0.70–1.97)1.13 (0.64–1.79)1.09 ± 0.33
 Production rate of total viral proteinpday−10.37 (0.22–0.59)0.59 (0.34–0.92)0.54 (0.31–0.86)0.50 ± 0.16
 Death rate of infected cellsδday−10.45 (0.32–0.64)0.54 (0.38–0.75)0.50 (0.36–0.68)0.50 ± 0.10
Quantities derived from fitted values
 Basic reproduction number through cell-free infectionRcf2.88 (2.34–3.53)2.27 (1.98–2.66)2.43 (2.04–2.95)2.44 ± 0.23
 Basic reproduction number through cell-to-cell infectionRcc2.95 (1.48–4.70)3.65 (1.77–6.05)3.39 (1.82–5.38)3.39 ± 0.91
 Basic reproduction numberR05.83 (4.20–7.75)5.92 (3.99–8.46)5.83 (4.21–7.89)5.83 ± 0.94
 Contribution of cell-to-cell infectionRccRcf+Rcc0.50 (0.34–0.63)0.60 (0.44–0.72)0.57 (0.43–0.70)0.57 ± 0.07
  • Mean value.

  • 95% confidence interval.

  • Average and standard deviation of merged values in experiment 1, 2, and 3.