Figure 1. | Genomic DNA transposition induced by human PGBD5

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Genomic DNA transposition induced by human PGBD5

Figure 1.

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Memorial Sloan Kettering Cancer Center, United States; Weill Cornell Medical College, United States; Harvard Medical School, United States; University of Utah School of Medicine, United States; Cornell University, United States
Figure 1.
Download figureOpen in new tabFigure 1. Human PGBD5 is a distinct piggyBac-like transposase.

Sequence alignment of piggyBac-like transposases frog Uribo 2, bat piggyBat, lepidopteran piggyBac, and human PGBD5. Catalytic residues conserved among piggyBac transposases are highlighted in red. Human PGBD5 D168, D194, and D386 residues, identified in our study (Figure 7), are marked in yellow.

DOI: http://dx.doi.org/10.7554/eLife.10565.003