Figure 4—figure supplement 1. | Epigenomic landscapes of retinal rods and cones

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Epigenomic landscapes of retinal rods and cones

Figure 4—figure supplement 1.

Affiliation details

Johns Hopkins University School of Medicine, United States; The Salk Institute for Biological Studies, United States; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, United States; Janelia Research Campus, Howard Hughes Medical Institute, United States; University of California San Diego, United States; The University of Western Australia, Australia; Johns Hopkins University, United States
Figure 4—figure supplement 1.
Download figureOpen in new tabFigure 4—figure supplement 1. Additional examples of in vivo retinal electroporation of putative cone regulatory elements.

Cryosections of C57Bl/6J or Nrl heterozygote retinas (left) and Nrl KO retinas (right) from 3–4 week old mice after in vivo retinal electroporation at P0 of putative cone regulatory elements near cone-specific genes. Elements near Pde6h and Opn1sw induce GFP reporter expression in Nrl KO retina but not in WT retina. An element near Thrb induces GFP reporter expression in both WT and Nrl KO retinas. The TdT signal is a control for electroporation efficiency. The average % of electroporated (TdT+) cells that are GFP+ is shown. Coordinates of electroporated elements are listed in Supplementary file 6.

DOI: http://dx.doi.org/10.7554/eLife.11613.014