Figure 6—figure supplement 1. | The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

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The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

Figure 6—figure supplement 1.

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Cornell University, United States
Figure 6—figure supplement 1.
Download figureOpen in new tabFigure 6—figure supplement 1. Atomic basis of the sec7-1 phenotype.

The temperature sensitive allele sec7-1 represents an S402L mutation, corresponding to T. terrestris Sec7 residue S156. This serine stabilizes a loop near the interface between the DCB and HUS regions.

DOI: http://dx.doi.org/10.7554/eLife.12411.022