Figure 1—figure supplement 5. | Modulation of anxiety and fear via distinct intrahippocampal circuits

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Modulation of anxiety and fear via distinct intrahippocampal circuits

Figure 1—figure supplement 5.

Affiliation details

McLean Hospital, United States; Harvard Medical School, United States; The University of Tennessee Health Science Center, United States; Yale School of Medicine, United States; Russian Academy of Sciences, Russia; University of Zurich, Switzerland
Figure 1—figure supplement 5.
Download figureOpen in new tabFigure 1—figure supplement 5. Tests of hippocampal function.

(A) Mean ( ± S.E.M.) percentage of time spent freezing during the tone 24 hr after auditory fear-conditioning using a delay (black) or trace (white) protocol.*p<0.05, ***p<0.001, different from the corresponding delay group. No significant differences were found in planned pair-wise comparisons of the genotypes within the trace-conditioned groups or within the delay-conditioned groups. (B) Mean ( ± S.E.M.) percentage of time spent freezing during re-exposure to the context 24 hr after contextual fear-conditioning. ***p<0.001, different from α2F/F. (C) Mean ( ± S.E.M.) distance to platform during probe trials. *p<0.05, ***p<0.001, different from α2F/F; gray: α2CA3KO, red: α2DGKO.

DOI: http://dx.doi.org/10.7554/eLife.14120.008