Table 1. | Modulation of anxiety and fear via distinct intrahippocampal circuits

Open accessCopyright infoDownload PDFDownload figures

Modulation of anxiety and fear via distinct intrahippocampal circuits

Table 1.

Affiliation details

McLean Hospital, United States; Harvard Medical School, United States; The University of Tennessee Health Science Center, United States; Yale School of Medicine, United States; Russian Academy of Sciences, Russia; University of Zurich, Switzerland
Table 1.

Results of omnibus statistical tests of experiments for the general characterization of α2CA1KO, α2CA3KO and α2DGKO mice.

DOI: http://dx.doi.org/10.7554/eLife.14120.009

1. Immunohistochemistry
One-Way ANOVA; Factor: Genotype
α2 Subunitα1 Subunitα5 Subunit
CA1F(3,10)=9.44P=0.003F(3,9)=0.08p=0.97F(3,9)=0.10p=0.96
CA3F(3,10)=5.05P=0.02F(3,9)=0.01p=0.99F(3,9)=0.13p=0.94
DGF(3,10)=9.08P=0.003F(3,9)=0.00p=1.00F(3,9)=0.06p=0.98
CortexF(3,10)=1.90p=0.19F(3,9)=0.01p=0.83F(3,9)=0.01p=0.99
AmygdalaF(3,10)=1.28p=0.34F(3,9)=0.21p=0.89F(3,9)=0.36p=0.78
2. Quantitative PCR
One-Way ANOVA; Factor: Genotype
α2 Subunitα3 Subunitα4 Subunit
CA1F(3,16)=10.66p<0.001F(3,16)=0.10p=0.96F(3,16)=2.48p=0.1
CA3F(3,16)=10.53p<0.001F(3,16)=0.67p=0.58F(3,16)=4.74p=0.02
DGF(3,16)=7.32p=0.003F(3,12)=1.96p=0.17F(3,12)=2.90p=0.08
CortexF(3,16)=15.69p<0.001
AmygdalaF(3,16)=3.01p=0.06
3. Slice Electrophysiology
Two-Way Mixed Factorial ANOVA; Factors: Genotype (between-subjects), Drug (within-subjects)
CA1AmplitudeFrequencyDecay Time
GenotypeF(1,38)=1.83p=0.18F(1,38)=2.80p=0.10F(1,38)=1.94p=0.17
DrugF(1,38)=1.49p=0.23F(1,38)=9.38p=0.004F(1,38)=107.96p<0.001
Genotype x Drug InteractionF(1,38)=2.91p=0.09F(1,38)=3.11p=0.08F(1,38)=0.82p=0.37
CA3AmplitudeFrequencyDecay Time
GenotypeF(1,21)=2.36p=0.14F(1,21)=1.85p=0.19F(1,21)=0.95p=0.34
DrugF(1,21)=0.66p=0.42F(1,21)=0.09p=0.77F(1,21)=30.54p<0.001
Genotype x Drug InteractionF(1,21)=0.21p=0.65F(1,21)=1.90p=0.18F(1,21)=0.25p=0.62
DGAmplitudeFrequencyDecay Time
GenotypeF(1,21)=1.50p=0.23F(1,21)=1.58p=0.22F(1,21)=0.01p=0.91
DrugF(1,21)=2.58p=0.12F(1,21)=1.58p=0.22F(1,21)=47.42p<0.001
Genotype x Drug InteractionF(1,21)=0.54p=0.47F(1,21)=1.33p=0.26F(1,21)=0.30p=0.59
4. Tests of Hippocampal Function
Delay – Trace Fear Conditioning
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Condition (between-subjects)
% Freezing
GenotypeF(3,49)=0.38p=0.77
ConditionF(1,49)=41.57p<0.001
Genotype x Cond. InteractionF(3,49)=0.71p=0.55
Contextual Fear Conditioning
One-Way ANOVA; Factor: Genotype (between-subjects)
% Freezing
GenotypeF(3,35)=5.47p=0.003
Morris Water Maze
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Day (within-subjects)
Time to platform
GenotypeF(3,80)=5.17p=0.01
DayF(5,80)=244.12p<0.001
Genotype x Day InteractionF(5,80)=1.36p=0.19