Table 4. | Modulation of anxiety and fear via distinct intrahippocampal circuits

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Modulation of anxiety and fear via distinct intrahippocampal circuits

Table 4.

Affiliation details

McLean Hospital, United States; Harvard Medical School, United States; The University of Tennessee Health Science Center, United States; Yale School of Medicine, United States; Russian Academy of Sciences, Russia; University of Zurich, Switzerland
Table 4.

Omnibus statistical tests of measured parameters in in vivo LFP recordings collected from ventral and dorsal hippocampus.

DOI: http://dx.doi.org/10.7554/eLife.14120.021

VENTRAL HIPPOCAMPUS
1. Peak Theta Frequency
Two-Way ANOVA; Factors: Stimulation intensity (within-subjects), Time before/after drug (within-subjects)
α2F/Fα2CA1KO
Stimulation intensityF(4,32)=9.13p<0.001F(4,24)=18.12p<0.001
Time after drugF(2,32)=22.98p<0.001F(2,24)=37.01p<0.001
Stimulation x TimeF(8, 32)=4.27p<0.001F(8,24)=9.07p<0.001
α2CA3KOα2DGKO
Stimulation intensityF(4,32)=8.14p<0.001F(4,32)=3.84P=0.02
Time after drugF(2,32)=6.14P=0.02F(2,32)=2.47P=0.15
Stimulation x TimeF(8, 32)=3.14P=0.01F(8, 32)=6.63p<0.001
2. Stimulation Intensity – Theta Frequency Slope
One-Way ANOVA; Factor: Genotype (between-subjects)
30min post-diazepam60min post-diazepam
GenotypeF(3,15)=3.94p=0.03F(3,73)=0.84p=0.48
3. Normalized Power
One-Way ANOVA; Factor: Genotype (between-subjects)
60min post-diazepam
GenotypeF(3,15)=4.65p=0.02
DORSAL HIPPOCAMPUS
4. Peak Theta Frequency
Two-Way ANOVA; Factors: Stimulation intensity (within-subjects), Time before/after drug (within-subjects)
α2F/Fα2CA1KO
Stimulation intensityF(4,32)=8.19p<0.001F(4,32)=5.29p=0.01
Time after drugF(2,32)=31.65p<0.001F(2,32)=3.03p<0.11
Stimulation x TimeF(8,32)=8.87p=0.003F(8,32)=1.89p=0.10
α2CA3KOα2DGKO
Stimulation intensityF(4,40)=19.19p<0.001F(4,32)=8.86p<0.001
Time after drugF(2,40)=27.08p<0.001F(2,32)=9.25p=0.01
Stimulation x TimeF(8,40)=4.30p<0.001F(8,32)=2.39p=0.04
5. Stimulation Intensity – Theta Frequency Slope
One-Way ANOVA; Factor: Genotype (between-subjects)
30min post-diazepam60min post-diazepam
GenotypeF(3,17)=2.97p=0.14F(3,17)=4.32p=0.02
6. Normalized Power
One-Way ANOVA; Factor: Genotype (between-subjects)
60min post-diazepam
GenotypeF(3,15)=1.02p=0.41