Figure 6—figure supplement 1. | Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Figure 6—figure supplement 1.

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University of Washington, United States; Fred Hutchinson Cancer Research Center, United States; University of Missouri, United States
Figure 6—figure supplement 1.
Download figureOpen in new tabFigure 6—figure supplement 1. Effect of rapamycin on the fecal microbiome.

(A) Heatmap of the Log2 16S rRNA gene abundance by mouse (column) and operation taxonomy units (OTU)s (row). The clustering is done on a subset of the OTUs with total abundance of more than 10 and relatively large variability (standard deviation of more than 1). Batch numbers indicates mice shipped and received into our facility at the same time. Feed and Inject indicate drug delivery via encapsulated feed and via injection, respectively. The hierarchical clustering shows the large effects of drug delivery method and batch effect on the microbial composition. (B) Table of P values from multivariate analysis for rapamycin vs. control (treatment), female vs. male (sex), mouse cages received into our facility at different times (batch) and injection vs. feeding regimen (delivery). *p<0.05. **p<0.01. ***p<0.001.

DOI: http://dx.doi.org/10.7554/eLife.16351.025