• Table 1.

    Sex-segregated comparison of median and mean post-treatment life expectancy for mice receiving rapamycin by injection (8 mg/kg/day) or feeding (128 ppm). M: males, F: females.

    DOI: http://dx.doi.org/10.7554/eLife.16351.008

    Median life expectancy (days)Percent life expectancy increaseMean life expectancy (days)Percent life expectancy increase
    Vehicle M231235
    Rapamycin (8mg/kg/day) M3726135853
    Vehicle F161177
    Rapamycin (8mg/kg/day) F1610171-3
    Eudragit M193199
    Rapamycin (126 ppm) M27944.624221
    Eudragit F184175
    Rapamycin (126 ppm) F2563924037
  • Table 2.

    Sex-segregated comparison of median and mean lifespan for mice receiving rapamycin by injection (8 mg/kg/day) or feeding (128 ppm). M: males, F: females.

    DOI: http://dx.doi.org/10.7554/eLife.16351.009

    Median lifespan (days)Percent median lifespan increaseMean lifespan (days)Percent mean lifespan increase
    Vehicle M925929
    Rapamycin (8mg/kg/day) M105414105013
    Vehicle F847858
    Rapamycin (8mg/kg/day) F8470853-1
    Eudragit M914912
    Rapamycin (126 ppm) M1037149848
    Eudragit F879883
    Rapamycin (126 ppm) F96099518
  • Table 3.

    Sex-pooled comparison of median and mean post-treatment life expectancy for mice receiving rapamycin by injection (8 mg/kg/day) or feeding (128 ppm).

    DOI: http://dx.doi.org/10.7554/eLife.16351.016

    Median life expectancy (days)Percent life expectancy increaseMean Life expectancy (days)Percent life expectancy increase
    Vehicle188204
    Rapamycin (8mg/kg/day)2312225726
    Eudragit190188
    Rapamycin (126 ppm)2704225737
  • Table 4.

    Sex-pooled comparison of median and mean lifespan for mice receiving rapamycin by injection (8 mg/kg/day) or feeding (128 ppm).

    DOI: http://dx.doi.org/10.7554/eLife.16351.021

    Median lifespan (days)Percent median lifespan increaseMean lifespan (days)Percent mean lifespan increase
    Vehicle874892
    Rapamycin (8mg/kg/day)92259445
    Eudragit885899
    Rapamycin (126 ppm)996139688
  • The following dataset was generated:

    Ito TK, Yajima M, 2015,Transient rapamycin treatment robustly increases lifespan and healthspan in middle-aged mice, http://www.ebi.ac.uk/ena/data/view/ERP014805, Publicly available at the EBI European Nucleotide Archive (accession no: ERP014805)