Figure 3—figure supplement 2. | Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

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Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

Figure 3—figure supplement 2.

Affiliation details

Nencki Institute of Experimental Biology of Polish Academy of Sciences, Poland; Polish Academy of Sciences, Poland; Warsaw University of Technology, Poland; University of Zurich, Switzerland; Kwazulu-Natal University Durban, Republic of South Africa
Figure 3—figure supplement 2.
Download figureOpen in new tabFigure 3—figure supplement 2. Eco-HAB allows for long-term monitoring of responses to social stimuli.

We assessed subjects approach to social odor in four different periods, namely 30’, 1 hr, 2 hr, and 4 hr after the presentation of olfactory stimuli, in order to see how their behavior changes with time. Approach to social odor in (a) valproate-treated C57BL/6 mice (n = 26) gradually decreases during first 4 hr of testing, whereas in (b) valproate-treated BALB/c mice (n = 18) it is high and stable during this time. In control C57BL/6 mice (n = 35) and BALB/c mice (n = 20) approach to social odor gradually decreases with a faster decrease rate in C57BL/6 mice. Data are represented as mean, error bars represent SEM, *p<0.05, **p<0.01, ***p<0.001 (Mann-Whitney U-test).

DOI: http://dx.doi.org/10.7554/eLife.19532.017