Figure 4. | Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

Open accessCopyright infoDownload PDFDownload figures

Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

Figure 4.

Affiliation details

Nencki Institute of Experimental Biology of Polish Academy of Sciences, Poland; Polish Academy of Sciences, Poland; Warsaw University of Technology, Poland; University of Zurich, Switzerland; Kwazulu-Natal University Durban, Republic of South Africa
Figure 4.
Download figureOpen in new tabFigure 4. Social impairment of Fmr1 knockout mice compared to wild-type control measured in Eco-HAB.

Fmr1 knockouts, n = 22. Wild-type controls, n = 10. (a) Odor-based social preference in the Eco-HAB system defined as the increase in proportion of time spent in the compartment with social odor during the first hour after its presentation, divided by the proportion of time spent in the compartment with non-social stimulus. Histogram (b) shows the distribution of in-cohort sociability for all pairs of knockout and control animals. Data are mean values and error bars represent SEM, *p<0.05, **p<0.01, ***p<0.001 (Mann-Whitney U-test).

DOI: http://dx.doi.org/10.7554/eLife.19532.018

Figure 4—source data 1.Eco-HAB measured social approach and in-cohort sociability of Fmr1 knockouts and wild-type controls.

The names of the Excel sheets refer to corresponding figures and contain data used for analysis of the behavioral measures obtained by the implementation of Eco-HAB.py software (see 'Materials and methods').

DOI: http://dx.doi.org/10.7554/eLife.19532.019

Download source data [figure-4—source-data-1.media-5.xlsx]
Figure 4—source data 2.Eco-HAB measured social approach and in-cohort sociability of Fmr1 knockouts and wild-type controls.

The names of the Excel sheetsrefer to corresponding figures and contain data used for analysis of the behavioral measures obtained by the implementation of Eco-HAB.py software (see 'Materials and methods').

DOI: http://dx.doi.org/10.7554/eLife.19532.020

Download source data [figure-4—source-data-2.media-6.xlsx]