Figure 3—figure supplement 5. | TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Figure 3—figure supplement 5.

Affiliation details

Cold Spring Harbor Laboratory, United States; Stony Brook University, United States; Huntington Hospital, Northwell Health, United States; University of Southern California, United States; Cancer Research UK – Cambridge Institute, University of Cambridge, United Kingdom
Figure 3—figure supplement 5.
Download figureOpen in new tabFigure 3—figure supplement 5. Exposure to TGF-β does not alter the cell cycle distribution in cancer cell lines.

(A) TGF-β treatment does not alter the cell cycle distribution in U2OS cells. The histograms represent U2OS cell cycle distribution without or with TGF-β (1 ng/ml of each of TGF-β1 and TGF-β2, 9 hr). 10,000 cells were analyzed by FACS for each replicate of each sample. (B) Quantification of cell cycle distribution from U2OS and H1650 cells upon 9 hr treatment with TGF-β (1 ng/ml of each of TGF-β1 and TGF-β2). Each bar represents the mean ± SD of three replicates from two independent experiments.

DOI: http://dx.doi.org/10.7554/eLife.21615.021