Figure 4—figure supplement 3. | TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Figure 4—figure supplement 3.

Affiliation details

Cold Spring Harbor Laboratory, United States; Stony Brook University, United States; Huntington Hospital, Northwell Health, United States; University of Southern California, United States; Cancer Research UK – Cambridge Institute, University of Cambridge, United Kingdom
Figure 4—figure supplement 3.
Download figureOpen in new tabFigure 4—figure supplement 3. Knockdown efficiencies of the indicated siRNAs in U2OS-DR-GFP cells.

Efficiency of knockdown upon transfection with the indicated siRNA oligonucleotides, without or with pCBASce-I (plasmid expressing Sce-I endonuclease), and compared to scramble-siRNA-transfected control cells. Cells were collected 3 days post-transfection and analyzed for expression of the indicated mRNA. Each bar represents the mean ± SD of three replicates from two independent experiments. p-value **<0.005, ***<0.0005, paired t-test.

DOI: http://dx.doi.org/10.7554/eLife.21615.025