Figure 5—figure supplement 1. | TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Figure 5—figure supplement 1.

Affiliation details

Cold Spring Harbor Laboratory, United States; Stony Brook University, United States; Huntington Hospital, Northwell Health, United States; University of Southern California, United States; Cancer Research UK – Cambridge Institute, University of Cambridge, United Kingdom
Figure 5—figure supplement 1.
Download figureOpen in new tabFigure 5—figure supplement 1. Heat-map of normalized read counts of FACS-sorted cells based on CD44 and CD24 surface markers from patient tumor and from the H1650-derived isogenic cell line H1650-Isg-E4.

Heat-maps of normalized read counts across segment breakpoints (using Euclidian distance and ward clustering method) of CD44+/CD24− cells and CD44−/CD24+ cells sorted from (A) an NSCL tumor (patient #4) and (B) the H1650-derived isogenic cell line (H1650-isg-E4) are displayed. CD44−/ CD24+ cells are marked with a blue circle and CD44+/CD24− cells are marked with an orange circle. The cluster dendogram and heat-map of normalized read counts were generated using Ginkgo, an open-source web platform for interactive analyses of CNA (Garvin et al., 2015) (http://qb.cshl.edu/ginkgo).

DOI: http://dx.doi.org/10.7554/eLife.21615.027