The 152 words with rich meaning (that is, nouns [NN, NNS], adjectives [JJ, JJR] and verb forms [VBD, VBG, VBN, VBP, VBZ]) and four or more characters that appeared in at least one million PubMed records as of July 28, 2018. were/VBD patients/NNS cells/NNS study/VBP have/VBP been/VBN treatment/NN results/NNS cell/NN using/VBG group/NN used/VBN activity/NN increased/VBN protein/NN data/NNS levels/NNS other/NN found/VBD disease/NN compared/VBN significant/JJ expression/NN clinical/JJ analysis/NN effect/NN associated/VBN effects/NNS showed/VBD different/JJ studies/NNS high/JJ control/VB human/NN years/NNS observed/VBN time/NN cases/NNS higher/JJR blood/NN gene/NN groups/NNS rate/VBP such/JJ risk/NN response/NN present/JJ cancer/NN increase/VBP well/JJ system/NN changes/NNS normal/JJ patient/JJ first/JJ model/NN mean/NN role/NN acid/NN factors/NNS total/VBP function/NN method/NN health/NN number/VB level/NN therapy/NN development/NN performed/VBN growth/NN suggest/VB important/JJ mice/NNS type/NN days/NNS rats/NNS similar/JJ lower/JJR presence/NN children/NNS months/NNS women/NNS specific/JJ proteins/NNS potential/JJ obtained/VBN studied/VBN tumor/NN serum/NN tissue/NN reported/VBN binding/NN including/VBG subjects/NNS reduced/VBN factor/NN concentrations/NNS based/VBN plasma/NN findings/NNS identified/VBN receptor/NN differences/NNS care/VBP treated/VBN decreased/VBD test/NN measured/VBN addition/NN primary/JJ early/JJ concentration/NN case/NN diagnosis/NN following/VBG genes/NNS infection/NN conditions/NNS show/NN period/NN related/VBN induced/VBN examined/VBD evidence/NN investigated/VBN positive/JJ developed/VBN range/NN demonstrated/VBN determined/VBN revealed/VBD several/JJ activation/NN samples/NNS liver/NN surgery/NN same/JJ major/NN values/NNS greater/JJR survival/NN species/NN shown/VBN acute/JJ determine/VB brain/NN population/NN complex/JJ pressure/NN bone/NN vitro/NN drug/NN