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Reddit IAmA: Paul Brindley on using CRISPR/Cas9 to limit the harmful impact of parasitic worms

eLife author Paul Brindley will discuss how he and his colleagues used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for causing schistosomiasis and liver fluke infection.
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Paul Brindley, Professor of Microbiology at the George Washington University, Washington DC will be answering questions about his research in February's Reddit IAmA in association with eLife.

In two recent articles published in eLife (https://elifesciences.org/articles/41337 and https://elifesciences.org/articles/41463), his team described how they successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer.

The genes they ‘knocked out’ of the worms using CRISPR/Cas9 resulted in markedly diminished symptoms of infection in animal models. Their results reveal how this revolutionary tool can be adapted to study parasitic worms, which are a major public health problem in tropical climates such as those in Southeast Asia, sub-Saharan Africa, and Latin America.

Paul will be answering questions about their two articles and their research more broadly at 4pm GMT (11am EST), February 13 on Reddit’s r/IAmA platform.

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