Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
Ana Lilia Juárez-Vázquez, Janaka N Edirisinghe ... Francisco Barona-Gómez
An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
Marco Novais-Cruz, Maria Alba Abad ... Cristina Ferrás
Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.
Joseph Wayne M Fowler, Rong Zhang ... William C Sessa
Detailed biochemical and metabolic analysis of the inflammatory response in human endothelial cells reveals that inflammation directly regulates cholesterol homeostasis.
Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.
Qiushuang Wu, Santiago Gerardo Medina ... Ariel Alejandro Bazzini
Genomic-profiles and reporters reveal that the three-nucleotide ‘words’ read by the ribosome, codons, have a strong effect on mRNA stability, impacting the homeostatic mRNA and protein levels in human cells.
Hundreds of cell growth and stress response genes are controlled by a rare small RNA component of an ancient splicing machinery, providing a raison d'être for its previously unexplained evolutionary conservation.
Exploratory growth is a newly discovered mode of Streptomyces growth that it is stimulated by fungi, is pH responsive, and can be communicated to other – physically separated – streptomycetes through airborne compounds.
The tumor suppressor p53 prevents tumor cell growth by employing a small RNA called miR-139-5p to inhibit the activity of an tumorigenic protein, cAMP-specific phosphodiesterase 4D.