9,389 results found
    1. Neuroscience

    Monitoring ATP dynamics in electrically active white matter tracts

    Andrea Trevisiol, Aiman S Saab ... Johannes Hirrlinger
    ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.
    1. Computational and Systems Biology

    Active contraction of microtubule networks

    Peter J Foster, Sebastian Fürthauer ... Daniel J Needleman
    Microtubule networks in frog egg extracts can spontaneously contract in a manner that can be quantitatively described by an active fluid model.
    1. Physics of Living Systems

    Large-scale orientational order in bacterial colonies during inward growth

    Mustafa Basaran, Y Ilker Yaman ... Askin Kocabas
    When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.
    1. Cell Biology

    Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

    Fan Ye, David K Breslow ... Maxence V Nachury
    Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.
    1. Physics of Living Systems

    Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

    Rachel A Banks, Vahe Galstyan ... Rob Phillips
    Mesoscopic properties of motor-microtubule assemblies, such as contractile rates and length scales, can be quantitatively connected to single-motor properties of kinesin motors.
    1. Physics of Living Systems

    Controlling contractile instabilities in the actomyosin cortex

    Masatoshi Nishikawa, Sundar Ram Naganathan ... Stephan W Grill
    Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.
    1. Chromosomes and Gene Expression

    Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

    Juncao Xu, Kaijie Cui ... Yu Zhang
    The cryo-EM structure of Escherichia coli Crl–TAC reveals the mechanism of DNA-contact-independent transcription activation.
    1. Cell Biology
    2. Computational and Systems Biology

    Active machine learning-driven experimentation to determine compound effects on protein patterns

    Armaghan W Naik, Joshua D Kangas ... Robert F Murphy
    In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
    1. Genetics and Genomics
    2. Neuroscience

    Parallel functional testing identifies enhancers active in early postnatal mouse brain

    Jason T Lambert, Linda Su-Feher ... Alex S Nord
    Methods for screening hundreds of DNA sequences for enhancer activity have been extended for use in vivo, uncovering novel enhancer elements active in the early postnatal brain.
    1. Physics of Living Systems

    Dynamic density shaping of photokinetic E. coli

    Giacomo Frangipane, Dario Dell'Arciprete ... Roberto Di Leonardo
    The concentration of motile bacteria, expressing a light-driven proton pump, can be precisely controlled in space and time by spatially modulating their swimming speeds with a structured light pattern.

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