Andrea Trevisiol, Aiman S Saab ... Johannes Hirrlinger
ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.
When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.
Mesoscopic properties of motor-microtubule assemblies, such as contractile rates and length scales, can be quantitatively connected to single-motor properties of kinesin motors.
Masatoshi Nishikawa, Sundar Ram Naganathan ... Stephan W Grill
Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.
Armaghan W Naik, Joshua D Kangas ... Robert F Murphy
In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
Methods for screening hundreds of DNA sequences for enhancer activity have been extended for use in vivo, uncovering novel enhancer elements active in the early postnatal brain.
Giacomo Frangipane, Dario Dell'Arciprete ... Roberto Di Leonardo
The concentration of motile bacteria, expressing a light-driven proton pump, can be precisely controlled in space and time by spatially modulating their swimming speeds with a structured light pattern.