1,870 results found
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Coevolutionary dynamics via adaptive feedback in collective-risk social dilemma game

    Linjie Liu, Xiaojie Chen, Attila Szolnoki
    The two-way coupling between collective actions and risk is essential to avoid the tragedy of the commons.
    1. Neuroscience

    Dynamic top-down biasing implements rapid adaptive changes to individual movements

    Lucas Y Tian, Timothy L Warren ... Michael S Brainard
    Multi-area recordings reveal how communication between two songbird brain areas conveys a top-down bias that adaptively modifies ongoing singing to support context-specific vocal learning.
    1. Neuroscience

    Adaptive coding for dynamic sensory inference

    Wiktor F Młynarski, Ann M Hermundstad
    To make reliable but metabolically efficient perceptual inferences in a changing world, neural systems should dynamically adapt based on surprise and uncertainty about the sensory environment.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha, René Lutter ... Edgar Delgado Eckert
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    The evolution of adhesiveness as a social adaptation

    Thomas Garcia, Guilhem Doulcier, Silvia De Monte
    Mathematical modeling supports a scenario where cell-cell adhesion gradually evolves through natural selection, leading to the emergence of cohesive aggregates in microbial populations.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Label-free imaging of immune cell dynamics in the living retina using adaptive optics

    Aby Joseph, Colin J Chu ... Jesse Schallek
    Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.
    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Evolutionary Biology

    Evolution of diversity in metabolic strategies

    Rodrigo Caetano, Yaroslav Ispolatov, Michael Doebeli
    Analytical and numerical analyses reveal that the number of coexisting species exceeds the number of resource only for the structurally unstable case of linear tradeoff.
    1. Cancer Biology
    2. Immunology and Inflammation

    Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

    Jason T George, Herbert Levine
    Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.

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