Lucas Y Tian, Timothy L Warren ... Michael S Brainard
Multi-area recordings reveal how communication between two songbird brain areas conveys a top-down bias that adaptively modifies ongoing singing to support context-specific vocal learning.
To make reliable but metabolically efficient perceptual inferences in a changing world, neural systems should dynamically adapt based on surprise and uncertainty about the sensory environment.
Anirban Sinha, René Lutter ... Edgar Delgado Eckert
Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
Mathematical modeling supports a scenario where cell-cell adhesion gradually evolves through natural selection, leading to the emergence of cohesive aggregates in microbial populations.
Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.
Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
Rodrigo Caetano, Yaroslav Ispolatov, Michael Doebeli
Analytical and numerical analyses reveal that the number of coexisting species exceeds the number of resource only for the structurally unstable case of linear tradeoff.
Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.