227 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

    Daniel M Cohen, Kyoung-Jae Won ... David J Steger
    The transcription factor C/EBPβ binds to different DNA sequences depending on whether it binds to ATF4, which enables C/EBPβ to conduct diverse transcriptional programs during adipocyte differentiation by exploiting an expanded motif repertoire.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

    Ayala Tovy, Jaime M Reyes ... Margaret A Goodell
    Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.
    1. Cell Biology
    2. Developmental Biology

    Dual functions of TAF7L in adipocyte differentiation

    Haiying Zhou, Tommy Kaplan ... Robert Tjian
    A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
    1. Cell Biology

    A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

    Xiao Zhang, Hero Robles ... Erica L Scheller
    A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age and in states of metabolic stress.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

    Hanghang Liu, Akane Wada ... Clifford J Rosen
    Loss or PTH1R-mediated repression of Zfp467 results in a pathway that increases Pth1r transcription via NFκB1 and thus cellular responsiveness to PTH/PTHrP, ultimately leading to enhanced bone formation.
    1. Developmental Biology

    Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice

    Yu Shi, Fanxin Long
    Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
    1. Neuroscience

    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Eiko Iwakoshi-Ukena, Kenshiro Shikano ... Kazuyoshi Ukena
    Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
    1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber
    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
    1. Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro, Gianfranco Peluso ... Giovanni Di Bernardo
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Developmental Biology

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu, Allyson K Palmer ... James L Kirkland
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.

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