491 results found
    1. Cell Biology

    Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

    Chelsea Hepler, Bo Shan ... Rana K Gupta
    Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
    1. Immunology and Inflammation

    MicroRNAs of the miR-17~92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

    Xiang Zhang, Jianguo Liu ... Xiaoyu Hu
    miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
    1. Developmental Biology

    TAF7L modulates brown adipose tissue formation

    Haiying Zhou, Bo Wan ... Robert Tjian
    TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.
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    1. Cell Biology
    2. Developmental Biology

    Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion

    Houyu Zhang, Yan Li ... Meng Xie
    A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Developmental Biology

    A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

    Javier Solivan-Rivera, Zinger Yang Loureiro ... Silvia Corvera
    A hybrid mouse/human model using mesenchymal progenitor cells reveals dynamics of human adipose tissue development and mechanisms that may enhance human adipose thermogenic capacity.
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia, Yvonne JK Edwards ... Roger J Davis
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Cancer Biology
    2. Cell Biology

    Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

    Leying Chen, Qing You ... Shiyi Zhang
    Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
    1. Cell Biology

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius, Sam Virtue ... Antonio Vidal-Puig
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Cell Biology
    2. Developmental Biology

    Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor alpha

    Sunhye Shin, Yiyu Pang ... Yuwei Jiang
    Combined fate mapping and genetic deletion studies reveal that PDGFRα+ cells and PDGFRα gene itself are required for adipose tissue development but not for adult tissue homeostasis.

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