A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
Vladimir Chubanov, Silvia Ferioli ... Thomas Gudermann
Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
Neural progenitors reside in relative low oxygen in the subgranular zone (SGZ), and the higher tissue oxygen levels that these cells must face as they migrate away from the hypoxic areas and differentiate appear to cause oxidative damage and an early phase of cell death.
Fabian Hersperger, Tim Meyring ... Katrin Kierdorf
Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.
Loss of the RNA-binding protein TDP-43 impairs the survival of oligodendrocyte progenitors and reactivates growth of mature oligodendrocytes, resulting in inappropriate wrapping of neuronal somata and blood vessels.
NMDARs promote spine formation to control survival of adult-born granule cells, but gauge spine enlargement and recruitment of AMPARs in both developing and mature neurons.
Stephen Johnston, Sarah L Parylak ... Matthew Shtrahman
Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
Jui-Yi Hsieh, Brittany N Ulrich ... Diane M Papazian
Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.